YC Drug discovery

35 companies · 29 active · 37% AI · most in S19 (4)

Atlas DiscoveryAI-native pharma companyYC S26San FranciscoStartup →AI

Anto BiosciencesA Foundation Model for Microbial Communities.YC F25San FranciscoStartup →AI

Paceline BioBiospecimen logistics & operations layer to accelerate drug devYC F25BoulderStartup →Other

ACXNext-generation biocides for sustainable agriculture at scaleYC S24New York CityStartup →AI

Ångström AIGen AI molecular simulations that reproduce wetlab resultsYC S24San FranciscoStartup →Other

BiocartesianConverting biology into digital molecular mapsYC S24PhiladelphiaStartup →Other

Eris BiotechOur drugs engage the immune system to fight tumorsYC W24Salt Lake CityStartup →Other

ParcelBioElevated mRNA for transformative medicines.YC W24San FranciscoStartup →Other

Velorum TherapeuticsBreakthrough medicines unlocking the biology of hemeYC W24San FranciscoStartup →Other

Adventris PharmaceuticalsAdventris makes cancer vaccinesYC W23BaltimoreStartup →Other

InvitrisCreating new protein-based drugs at scaleYC W23MunichStartup →AIInactive

Lavo Life SciencesAI for drug formulationYC W23Startup →Other

Relevium MedicalPlatform injectable gel based therapeutic for osteoarthritisYC S22GalwayStartup →Other

AlixiaTargeting the Tumor Ecosystem to address cancer drug resistance.YC W22San FranciscoStartup →OtherAcquired

Engage BioPotent, durable, and redosable non-viral genetic medicinesYC W22San FranciscoStartup →DataInactive

FlowDeployBioinformatics pipelines in the cloudYC W22San FranciscoStartup →Other

Origami Therapeutics, Inc.Oral drugs to halt neurodegenerationYC W22San DiegoStartup →AI

Harmonic DiscoveryMulti-targeted therapeutics to treat complex diseasesYC S21New York CityStartup →Other

Talus BioDiscovering drugs that target the DNA regulomeYC S21SeattleStartup →OtherInactive

Forcyte BiotechnologiesDiscover drugs that control how much cells "squeeze" to treat diseaseYC W21Los AngelesStartup →Other

Serna BioGenetic Medicine with Small MoleculesYC W21San FranciscoStartup →Other

Valink TherapeuticsDiscovering bispecific antibody drug-conjugates (BsADC) against cancerYC W21BostonStartup →AI

Abalone BioWe create activating antibodies to treat diseases others can’t.YC W20San FranciscoStartup →AI

Algen BiotechnologiesUsing CRISPR to find treatments for cancer and inflammationYC W20San FranciscoStartup →AI

Altay TherapeuticsAltay develops disease-modifying therapies targeting transcription…YC W20San FranciscoStartup →Other

General ProximityThe next generation of induced-proximity medicines.YC W20San FranciscoStartup →AI

Arpeggio BioArpeggio Bio develops drugs targeting transcription factors using AI…YC S19BoulderStartup →OtherInactiveEncepheal TherapeuticsEncepHeal develops medications to treat substance abuse, starting…YC S19Winston-SalemStartup →AI

GEn1E LifesciencesAI platform accelerating therapies for rare & inflammatory diseases.YC S19San FranciscoStartup →Other

Sequence BioDiscovering the true signals of disease to power life-changing drugs.YC S19St. John'sStartup →Other

LEAH LabsLiving therapies for pets first, and their people nextYC W19MinneapolisStartup →Other

OncoboxFinding the right cancer drug for each patient.YC S17WalnutStartup →AI

SynviviaSynvivia applies chemical control over cell behaviorYC S16San FranciscoStartup →OtherPublic

Notable LabsPersonalized drug discovery for blood cancer.YC W15San FranciscoStartup →AI

Numerion LabsArtificial intelligence for drug discovery.YC W15San FranciscoStartup →

Company	Category	Status	Program
Atlas DiscoveryAI-native pharma companyteam of 3YC S26ActiveAI	AI	Active	YCS26
Anto BiosciencesA Foundation Model for Microbial Communities.team of 4YC F25ActiveAI	AI	Active	YCF25
Paceline BioBiospecimen logistics & operations layer to accelerate drug devteam of 3YC F25ActiveAI	AI	Active	YCF25
ACXNext-generation biocides for sustainable agriculture at scaleteam of 4YC S24ActiveOther	Other	Active	YCS24
Ångström AIGen AI molecular simulations that reproduce wetlab resultsteam of 5YC S24ActiveAI	AI	Active	YCS24
BiocartesianConverting biology into digital molecular mapsteam of 2YC S24ActiveOther	Other	Active	YCS24
Eris BiotechOur drugs engage the immune system to fight tumorsteam of 2YC W24ActiveOther	Other	Active	YCW24
ParcelBioElevated mRNA for transformative medicines.team of 6YC W24ActiveOther	Other	Active	YCW24
Velorum TherapeuticsBreakthrough medicines unlocking the biology of hemeteam of 5YC W24ActiveOther	Other	Active	YCW24
Adventris PharmaceuticalsAdventris makes cancer vaccinesteam of 7YC W23ActiveOther	Other	Active	YCW23
InvitrisCreating new protein-based drugs at scaleteam of 6YC W23ActiveOther	Other	Active	YCW23
Lavo Life SciencesAI for drug formulationteam of 3YC W23InactiveAI	AI	Inactive	YCW23
Relevium MedicalPlatform injectable gel based therapeutic for osteoarthritisteam of 5YC S22ActiveOther	Other	Active	YCS22
AlixiaTargeting the Tumor Ecosystem to address cancer drug resistance.team of 2YC W22ActiveOther	Other	Active	YCW22
Engage BioPotent, durable, and redosable non-viral genetic medicinesteam of 10acquiredYC W22AcquiredOther	Other	Acquired	YCW22
FlowDeployBioinformatics pipelines in the cloudteam of 3YC W22InactiveData, Devtools	Data, Devtools	Inactive	YCW22
Origami Therapeutics, Inc.Oral drugs to halt neurodegenerationteam of 4YC W22ActiveOther	Other	Active	YCW22
Harmonic DiscoveryMulti-targeted therapeutics to treat complex diseasesteam of 8YC S21ActiveAI	AI	Active	YCS21
Talus BioDiscovering drugs that target the DNA regulometeam of 16YC S21ActiveOther	Other	Active	YCS21
Forcyte BiotechnologiesDiscover drugs that control how much cells "squeeze" to treat diseaseteam of 5YC W21InactiveOther	Other	Inactive	YCW21
Serna BioGenetic Medicine with Small Moleculesteam of 5YC W21ActiveOther	Other	Active	YCW21
Valink TherapeuticsDiscovering bispecific antibody drug-conjugates (BsADC) against cancerteam of 15YC W21ActiveOther	Other	Active	YCW21
Abalone BioWe create activating antibodies to treat diseases others can’t.team of 14YC W20ActiveAI	AI	Active	YCW20
Algen BiotechnologiesUsing CRISPR to find treatments for cancer and inflammationteam of 17YC W20ActiveAI	AI	Active	YCW20
Altay TherapeuticsAltay develops disease-modifying therapies targeting transcription…team of 6YC W20ActiveAI	AI	Active	YCW20
General ProximityThe next generation of induced-proximity medicines.team of 15hiringYC W20ActiveOther	Other	Active	YCW20
Arpeggio BioArpeggio Bio develops drugs targeting transcription factors using AI…team of 20YC S19ActiveAI	AI	Active	YCS19
Encepheal TherapeuticsEncepHeal develops medications to treat substance abuse, starting…team of 3YC S19InactiveOther	Other	Inactive	YCS19
GEn1E LifesciencesAI platform accelerating therapies for rare & inflammatory diseases.YC S19ActiveAI	AI	Active	YCS19
Sequence BioDiscovering the true signals of disease to power life-changing drugs.team of 52YC S19ActiveOther	Other	Active	YCS19
LEAH LabsLiving therapies for pets first, and their people nextteam of 4YC W19ActiveOther	Other	Active	YCW19
OncoboxFinding the right cancer drug for each patient.team of 11YC S17ActiveOther	Other	Active	YCS17
SynviviaSynvivia applies chemical control over cell behaviorteam of 4YC S16ActiveAI	AI	Active	YCS16
Notable LabsPersonalized drug discovery for blood cancer.team of 40publicYC W15PublicOther	Other	Public	YCW15
Numerion LabsArtificial intelligence for drug discovery.team of 67YC W15ActiveAI	AI	Active	YCW15

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