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Sift Biosciences

Supercharging existing cancer therapies.

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  • went through Plug and PlayProgram · this site+1

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About Sift Biosciences

Sift is developing first- and best-in-class T-cell modulators that address a critical unmet need in oncology: most solid tumors lack immunogenic targets and remain resistant to current immunotherapies. Sift differentiates by leveraging molecular mimicry, shared genomic sequences between microbes and humans, to design highly immunogenic cancer antigen variants derived from microorganisms. This novel approach activates an otherwise untapped repertoire of pre-existing memory T-cells originally trained against microbial infections. These microbe-reactive T-cells exhibit more robust functionality compared to conventional cancer-specific T-cells. Building upon our oncology proof-of-concept, Sift is also exploring platform applications to selectively expand target-specific regulatory T cells, with the potential to restore immune tolerance in autoimmune diseases. This dual applicability further highlights the transformative potential of our mimicry-based antigen engineering approach.

Category
Other
Location
United States
Checked
7h ago

Sift Biosciences: questions

Which accelerators did Sift Biosciences go through?

Sift Biosciences is listed by Plug and Play.

Where is Sift Biosciences based?

Sift Biosciences lists United States as its location on Plug and Play's page.