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14,448 startups · 29 programs

Frontier Computing

Active · Frontier grows scalable biological brains as an ML training substrate

WebsiteYC profile

Why it ranks

How the rank works
7signal of 100 · rising 7
  • went through YCProgram · this site+4
  • team of 3Team size · YC's directory+3.1

A sum of public facts, not a judgement and not investment advice.

Same space

AIAcquiredRain NeuromorphicsShared: hardware, neuron, brainYC S18San FranciscoStartup →OtherRushnuShared: highly cost, traditionalPlug and PlayUnited StatesStartup →AIDeepinventShared: frontierAntler 2025USStartup →AIRisklyticsShared: hardware, frontierYC F26San FranciscoStartup →AIDydemaShared: hardware, brain, scaleYC F26San FranciscoStartup →
Companies next to Frontier Computing
Company
Rain NeuromorphicsShared: hardware, neuron, brainYC S18AcquiredAI
RushnuShared: highly cost, traditionalPlug and Play Not statedOther
DeepinventShared: frontierAntler 2025Not statedAI
RisklyticsShared: hardware, frontierYC F26ActiveAI
DydemaShared: hardware, brain, scaleYC F26ActiveAI

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Founders

  • Michael DomarkasFounder/CEO

About Frontier Computing

Frontier is first to grow biological brains at scale, serving biological neural nets with substrate-level colocation of memory and compute, enabling highly cost effective training of large parameter count models. While academia has traditionally been limited to ~1M neurons in vitro, Frontier has built a pathway to scale to 100M+ neurons by circumventing traditional scaling challenges in biological culture, demonstrating this strategy's functionality by training a biological brain using this scaling primitive to play Frogger. Frontier is now growing exascale compute clusters to produce substrates capable of long-horizon language reasoning while operating at much higher sample efficiencies than traditional architectures, and collocating memory with compute to enable significantly larger parameter counts than would be tractable for training within traditional compute clusters.

YC batch
S26 · Summer 2026
Status, per YC
Active
Category
AI
Team size
3
Location
London, England, United Kingdom
Founded
2025
Checked
6h ago

YC tags: Hard Tech, Hardware, AI

Changes seen

Team sizeSep 25, 2026

Team went from 1 to 3 people.

Source ↗

Frontier Computing in S26: 229 companies, 88% AI

Frontier Computing: questions

Which YC batch was Frontier Computing in?

Frontier Computing was in Y Combinator's Summer 2026 batch (S26).

Is Frontier Computing still active?

Y Combinator lists Frontier Computing as active.

Who founded Frontier Computing?

Frontier Computing's founders, as listed on its YC page: Michael Domarkas (Founder/CEO).

Where is Frontier Computing based?

Frontier Computing lists London, England, United Kingdom as its location on YC's directory.